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Lowering systemic inflammation reduces pain and improves movement, multiplying the health benefits of these medications

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Compared with db/db mice, the Low and High groups treated with berberine had lower blood glucose levels after intraperitoneal injection of glucose and insulin (Figures 1E, G)

These compound-specific effects could affect the way in which individual DPP4i are used therapeutically and potentially explain off-target adverse effects, such as hospitalization for heart failure, which is seen only with one DPP4i